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A Novel Improved Design for the First-generation Glucose Biosensor

Jie Liu1* and Joseph Wang2


1
Department of Chemistry, Nantong Medical College, Nantong, JS 226001, People’s Republic of China

2Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA

Article history:

Received May 17, 2000
Accepted October 26, 2000

Key words:

glucose, biosensors, enzyme electrode, metal-dispersed, carbon paste

Summary:

The historical development of three generations of enzyme-based amperometric glucose biosensors are compared. A novel design of the first-generation glucose biosensor based on the use of metal-dispersed carbon paste electrode is described. Such a strategy enables remarkable selectivity and improved sensitivity, without excluding or destroying the endogenous electroactive interferences, commonly associated with the first-generation glucose biosensor. It offers a strong, preferential electrocatalytic action towards the enzymatically- liberated hydrogen peroxide due to the proper selection of the transducer metal-dispersed material. On the other hand, a unique, non-polar pasting liquid allows efficient operation of the resulting glucose biosensor under severe depletion of oxygen or under a considerable period of thermal stress by providing an internal oxygen supply and establishing a micro-environment of the enzyme against thermoinactivation, respectively. Metal-dispersed carbon paste enzyme electrodes have thus become a promising new design of the first-generation biosensors, especially for blood glucose measurements and other biothechnical applications due to their remarkable selectivity, high stability, low oxygen- dependence, and good dynamic performance.



*Corresponding author:           ntjl@bigfoot.com
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