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Cytotoxicity, Platelet Aggregation Inhibitory and Antioxidant Activity of Curcuma amada Roxb. Extracts

Rudragoud S. Policegoudra1*, Raghu H. Chandrashekhar2, Somaradhya M. Aradhya3 and Lokendra Singh1

1Defence Research Laboratory, 784001 Tezpur, Assam, India
2Manipal College of Pharmaceutical Sciences, Manipal University, 576104 Manipal, Karnataka, India
3Central Food Technological Research Institute, 570020 Mysore, Karnataka, India

Article history:

Received March 3, 2010
Accepted December 9, 2010

Key words:

Curcuma amada, mango ginger, antioxidant activity, phenolics, platelet aggregation inhibitory activity, cytotoxicity

Summary:
  

Mango ginger (Curcuma amada Roxb.) is a unique spice having morphological resemblance to ginger but imparts raw mango flavour. The sequential extraction of mango ginger rhizome powder was carried out using hexane, chloroform, ethyl acetate, acetone, methanol and water. The phenolic content was the highest in methanol extract, followed by acetone, ethyl acetate and water extracts. Among these, chloroform extract exhibited high lipid peroxidation inhibitory activity and metal chelating activity, whereas ethyl acetate extract showed high DPPH radical scavenging activity and superoxide radical scavenging activity. Mango ginger extracts also showed potential platelet aggregation inhibitory activity and cytotoxicity properties.   


*Corresponding author:           poligene@rediffmail.com
                                               ++91 3712 258 508
                                               ++91 3712 258 534

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