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Extracts of Edible Plants Inhibit Pancreatic Lipase, Cholesterol Esterase and Cholesterol Micellization, and Bind Bile Acids

Sirichai Adisakwattana1,2*, Julnaryn Intrawangso3, Araya Hemrid3, Benjanut Chanathong1 and Kittana Mäkynen1,2


1The Medical Food Research and Development Center, Department of Nutrition and Dietetics,
Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand
2Research Group of Herbal Medicine for Prevention and Therapeutic of Metabolic Diseases, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand
3Undergraduate Program in Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan, 10330 Bangkok, Thailand

Article history:

Received June 2, 2010
Accepted February 23, 2011

Key words:

edible plants, pancreatic lipase, cholesterol micellization, pancreatic cholesterol esterase, bile acid binding

Summary:

The application of edible plants with more effective ability to inhibit fat digestion and absorption has recently been explored for possible treatment of hyperlipidaemia. The aim of the present study is to investigate the effect of nine edible plants on the inhibition of pancreatic lipase and pancreatic cholesterol esterase activities, as well as the inhibition of cholesterol micelle formation, and bile acid binding. Our findings have shown strong pancreatic lipase inhibitory activity and the inhibition of cholesterol micellization by mulberry leaf extract. Safflower extract was the most potent inhibitor of pancreatic cholesterol esterase. In addition, cat’s whiskers and safflower extracts had a potent bile acid binding activity. It is suggested that a daily intake of these edible plants may delay postprandial hypertriacylglycerolaemia and hypercholesterolaemia, and therefore may be applied for the prevention and treatment of hyperlipidaemia.

 


*Corresponding author:           Sirichai.a@chula.ac.th
                                               ++66 2 218 1067
                                               ++66 2 218 1076

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