Genetically Engineered Strains: Application and Advances for 1,3-Propanediol Production from Glycerol

Miaomiao Yang#small orcid_display_4pp, Junhua Yun#small orcid_display_4pp, Huanhuan Zhang#small orcid_display_4pp, Tinashe A. Magochasmall orcid_display_4pp, Hossain Zabedsmall orcid_display_4pp, Yanbo Xuesmall orcid_display_4pp, Ernest Fokumsmall orcid_display_4pp, Wenjing Sunsmall orcid_display_4pp and Xianghui Qi*small orcid_display_4pp

School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, 212013 Zhenjiang, Jiangsu, PR China

Article history:
Received: July 29, 2017
Accepted: November 23, 2017

Key words:
glycerol, 1,3-propanediol, biosynthesis, genetically engineered strain, mutagenesis

1,3-Propanediol (1,3-PD) is one of the most important chemicals widely used as monomers for synthesis of some commercially valuable products, including cosmetics, foods, lubricants and medicines. Although 1,3-PD can be synthesized both chemically and biosynthetically, the latter offers more merits over chemical approach as it is economically viable, environmentally friendly and easy to carry out. The biosynthesis of 1,3-PD can be done by transforming glycerol or other similar substrates using some bacteria, such as Clostridium butyricum and Klebsiella pneumoniae. However, these natural microorganisms pose some bottlenecks like low productivity and metabolite inhibition. To overcome these problems, recent research efforts have been focused more on the development of new strains by modifying the genome through different techniques, such as mutagenesis and genetic engineering. Genetically engineered strains obtained by various strategies cannot only gain higher yield than wild types, but also overcome some of the barriers in production by the latter. This review paper presents an overview on the recent advances in the technological approaches to develop genetically engineered microorganisms for efficient biosynthesis of 1,3-PD.

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These authors contributed equally to this work

Paper was presented at the 7th International Forum on Industrial Bioprocessing - IFIBiop 2017, May 21-24, 2017, Wuxi, PR China