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The Effect of Short-Toothed and Dalmatian Sage Extracts on Platelet Aggregation

Andrea Antolić1orcid tiny, Željan Maleš2orcid tiny, Maja Tomičić3orcid tiny and Mirza Bojić4*orcid tiny

1University of Zagreb, Faculty of Science, Roosevelt Square 6, HR-10000 Zagreb, Croatia
2University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Botany, Schrottova 39, HR-10000 Zagreb, Croatia
3Croatian Institute of Transfusion Medicine, Department of Platelet and Leukocyte Immunology, Petrova 6, HR-10000 Zagreb, Croatia
4University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, A. Kovačića 1, HR-10000 Zagreb, Croatia

Article history:
Received: 16 August 2017
Accepted: 15 December 2017

Key words:
sage, flavonoids, phenolic acids, platelet aggregation

Sage (Salvia sp.) is a genus of a native Mediterranean plant used for aromatization of foods. In this study, total polyphenolic profile, antioxidant properties and antiplatelet effect of short-toothed sage (Salvia brachyodon Vandas) are analyzed and compared to most commonly used Salvia species (S. officinalis, Dalmatian sage). Content of total flavonoids was 0.08-0.23 % and of phenolic acids 0.47-3.04 %. Antioxidant DPPH assay showed higher antioxidant capacity of S. brachyodon (29-36 mg/mL of gallic acid equivalents) than of S. officinalis. In functional test of primary haemostasis, extracts of S. brachyodon have prevented platelet aggregation in nanomolar concentration (21 nM), thus showing potential in prevention of thrombus formation as functional food or dietary supplement. Antiplatelet activity was related to antioxidant capacity (r=0.7014, p=0.0352) indicating that prevention of aggregation is not caused by an individual component, but it is rather a result of synergistic effect of polyphenols. The obtained results are preliminary and a more detailed study of the possibility of applying the investigated plant species as supplements for the prevention of the problem of cardiovascular system and platelet aggregation is needed.

*Corresponding author:  tel3  +38514818304
                                           fax2  +38516394400

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