getpdf

Combined Biocatalytic Preparation of (R)-2-Ethylhexanol and 2-Ethylhexyl Laurate

Blaženka Ćiško-Anić, Maja Majerić-Elenkov, Zdenko Hameršak and Vitomir Šunjić*


Ruđer Bošković Institute, Bijenička c. 54, P.O.B.1016, HR-10000 Zagreb, Croatia


Article history:

Received January 25, 1999
Accepted February 15, 1999

Key words:

Pseudomonas sp. lipase, kinetic resolution, (R)-2-ethylhexanol

Summary:

(R)-2-Ethylhexanol (R-1) is prepared in high optical purity (> 99 % enantiomeric excess, e.e.) by the Pseudomonas sp. lipase-catalyzed acylation of racemic 1 using vinyl laurate as the acylating agent that allows the isolation of (R)-1 by distillation. Nonactivated lauric acid proved to be very reactive, affording (R)-1 with > 99 % e.e., but difficulties in down-stream process disfavored its use. 2-Ethylhexyl laurate (3), the other product in this process, is also a commercially valuable material. Recycling of the enzyme and simple isolation of optically pure alcohol (R)-1 makes the method amenable to the scale-up. 



*Corresponding author:           sunjic@rudjer.irb.hr
                                               +385–1–4680 195

Search FTB


Follow us


 facebook 1 twitter bird_icon LI In Bug

 

QR Code


qrcode

We use cookies to improve our website and your experience when using it. Cookies used for the essential operation of the site have already been set. To find out more about the cookies we use and how to delete them, see our privacy policy.

I accept cookies from this site.

EU Cookie Directive Module Information