Signalling Stress in Yeast

Juan Carlos Igual¹ and Francisco Estruch^1,2*

¹Departamento de Bioquímica y Biología Molecular, Universitat de València
²Departamento de Biotecnología, IATA (CSIC), Apdo. Correos 73, 46100 Burjassot (Valencia), Spain

Article history:
Received October 31, 2000
Accepted November 29, 2000

Key words:
yeast, stress, heat-shock, nutrient signalling, cell integrity, transcription

Summary:
The response to environmental conditions involves a complex system of signal transduction pathways. These pathways allow the sensing of the external alteration and the transmission of the signal from the surface of the cell to the nucleus. In this way, the stress signals are converted into changes in gene expression. The proteins synthesized under these conditions allow damaged cells to be repaired and protected against further exposure to stress. In this review we analyze the stress-activated signal pathways in the yeast Saccharomyces cerevisiae. We will describe the progress made in recent years in studies about how the stress signal is sensed and transduced to the nucleus, how transcription factors are activated and which genes are induced.

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