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he Role of Vitamin D in Inflammatory Bowel Disease – Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification

Dunja Leskovar1#orcid tiny, Tomislav Meštrović2*#orcid tiny, Anja Barešić3, Ivana Kraljević4orcid tiny, Marina Panek1orcid tiny, Hana Čipčić
Paljetak1orcid tiny, Mihaela Perić1orcid tiny, Mario Matijašić1orcid tiny
Dunja Rogić4orcid tiny, Ana Barišić4orcid tiny, Dina Ljubas Kelečić4orcid tiny, Darija Vranešić Bender4orcid tinyŽeljko Krznarić4orcid tiny and Donatella Verbanac1,5orcid tiny


1University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
2Polyclinic “Dr. Zora Profozic”, Bosutska 19, 10 000 Zagreb, Croatia
3MRC London Institute of Medical Sciences, Du Cane Rd, London W12 0NN, United Kingdom
4University Hospital Centre, Kišpaticeva 12, 10 000 Zagreb, Croatia
5University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, 10 000 Zagreb, Croatia

Article history:
Received: 16 April 2018
Accepted: 19 November 2018

Key words:
inflammatory bowel diseases, Crohn’s disease, ulcerative colitis, vitamin D, gut microbiota, dysbiosis

Inflammatory bowel diseases are a group of chronic inflammatory conditions that affect gastrointestinal tract due to inapt and continuous immune activation in response to a myriad of predisposing factors (most notably genetics, environmental impact and gut microbiota composition). It has been shown that vitamin D status can also play a role in the disease pathogenesis, as its deficiency is commonly observed in two major forms of inflammatory bowel diseases – Crohn’s disease and ulcerative colitis. Mounting evidence supports the concept of intricate relationship between gut dysbiosis and vitamin D metabolism, while suboptimal levels of this vitamin have been linked to increased clinical disease relapse rates, inadequate response to drugs, as well as decreased quality of life in patients with Crohn’s disease and ulcerative colitis. Consequently, the pertinent question is whether increased vitamin D supplementation and (on a population level) food fortification may bring significant benefit to the affected individuals. In this short review we discuss the synthesis, functions, status and food sources of vitamin D, appraise biotechnological facets of vitamin D status analysis and food fortification, and concentrate on novel developments in the field that describe its influence on intestinal microbiota and inflammatory bowel disease.

*Corresponding author:  tel3  +38516112501
                                           fax2  +38516115651
                                           email3  This email address is being protected from spambots. You need JavaScript enabled to view it.

These authors contributed equally to this work