Production of Astaxanthin by Xanthophyllomyces dendrorhous ZJUT46 with Fed-Batch Fermentation in 2.0 M³ Fermentor

Zhong-Ce Hu, Yu-Guo Zheng*, Zhao Wang and Yin-Chu Shen

Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China

Article history:
Received June 23, 2005
Accepted April 26, 2006

Key words:
astaxanthin, fed-batch fermentation, carotenoid, Xanthophyllomyces dendrorhous

Summary:
Astaxanthin is a main carotenoid pigment. Fed-batch fermentation bioprocesses of astaxanthin in 2.0 M³ fermentor have been investigated. Moreover, pH shift control was employed in fed-batch fermentation at 2.0 M³ scale. The results of astaxanthin fermentation showed that the fed-batch fermentation with pH shift strategy was the best among all the experiments, and the maximum astaxanthin concentration of 39.47 mg/L was achieved at 132 h.

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