New Approach to Inactivation of Harmful and Pathogenic Microorganisms by Photosensitization
Živilė Lukšienė
Institute of Material Science and Applied Research, Vilnius University, Saulėtekio 9, LT-10223, Vilnius, Lithuania
Article history:
Received October 11, 2004
Accepted September 26, 2005
Key words:
photosensitization, inactivation microorganisms
Summary:
Photosensitization is a treatment involving the administration of a photoactive compound that selectively accumulates in the target cells or microorganisms and is followed by irradiation with visible light. The combination of the two absolutely nontoxic elements, drug and light, in the presence of oxygen results in the selective destruction of target microorganism. It is important to note that truly major advances have been made in photosensitized antimicrobial chemotherapy, in particular disinfection of the blood and blood products, or treating local infections. By no means, prevention of any disease by microbial control of environment, including food manufacturing, is of greatest importance. Thus, development of new antimicrobial methods is necessary. In this context, photosensitization has been shown to be really effective: different microorganisms such as drug-resistant bacteria, yeasts, viruses and parasites can be inactivated by this method. So far, a photosensitization phenomenon can open new and interesting avenues for the development of novel, effective and ecologically friendly antimicrobial treatment, which might be applied to increase food safety.
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