Regulation of the Cyanide-Resistant Alternative Respiratory Pathway in the Fungus Acremonium chrysogenum

Erzsébet Sándor, Erzsébet Fekete and Levente Karaffa*

Department of Microbiology and Biotechnology, Faculty of Sciences, University of Debrecen, H-4010, P.O.Box 63, Debrecen, Hungary

Article history:
Received: September 17, 2002
Accepted: January 24, 2003

Key words:
Acremonium chrysogenum, alternative oxidase, respiration, oxygen, peroxides, cephalosporin C, soybean oil

Summary:
This review summarises the current knowledge on the biochemical and physiological events that directly or indirectly alter the engagement of the cyanide-resistant alternative respiratory pathway in the cephalosporin C producer filamentous fungus Acremonium chrysogenum. Particular emphasis is placed on the role this activity plays in the overproduction of antibiotic, and also on the critical fermentation technology background that supports its operation.

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