Electrophoresis on Novel Gel Matrices

Branko Kozulić*

Elchrom Scientific AG, Gewerbestrasse 8, 6330 Cham, Switzerland

Article history:
Received January 25, 1999
Accepted February 15, 1999

Key words:
DNA electrophoresis, new matrices, Spreadex gels

Summary:
In recent years, significant progress has been made in the development of new matrices for gel electrophoresis as well as in our understanding of the mechanism governing the migration of large molecules through gels. This review will describe some of these developments. It will be shown that gels of new generation, called Spreadex gels, possess resolving power that is 2–3 fold higher compared to resolving power of polyacrylamide gels. About 8 cm long Spreadex gels enable the separation of double stranded DNA fragments which differ by a single base pair.

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